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5-Amino-1MQ: Metabolic / Longevity research guide
In short: 5-Amino-1MQ is a selective NNMT inhibitor that preserves intracellular NAD+ and SAM pools by blocking nicotinamide methylation in adipose tissue. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.
Not medical advice. 5-Amino-1MQ is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
5-Amino-1MQ at a glance
What to know first
Details and limits sit in the sections below. Research use only.
What 5-Amino-1MQ is
5-Amino-1MQ is a selective NNMT inhibitor small molecule that preserves intracellular NAD+ and SAM pools, reduces adipocyte hypertrophy, and improves grip strength in diet-induced obesity models.
One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.
5-Amino-1MQ is a selective NNMT inhibitor that preserves intracellular NAD+ and SAM pools by blocking nicotinamide methylation in adipose tissue.
Research contexts
Peer-reviewed papers discuss 5-Amino-1MQ in specific lab settings. The points below reflect research questions, not health claims.
Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.
Typical study contexts
Why Metabolic / Longevity research matters
Researchers study these compounds for mitochondrial function and cellular energy stress. Ageing and metabolic disease models are common.
Mechanisms (technical review)
Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.
Lab handling & preparation
Common Questions People Are Asking
What is 5-Amino-1MQ used for in research?
In the literature 5-Amino-1MQ is used as a selective NNMT inhibitor tool compound to study fat-cell metabolism, NAD+ and SAM biology, and diet-induced obesity. Preclinical mouse studies have looked at whether blocking NNMT shrinks adipocytes, lowers body weight, and improves glucose handling. It is supplied here for laboratory research only and is not for human use.
Is 5-Amino-1MQ a peptide?
No - it is a small molecule (5-amino-1-methylquinolinium) not a peptide. It is included in the research metabolic toolkit because it targets an enzyme pathway (NNMT) that affects the same NAD+ and SAM pools that peptide-based metabolic research often tries to influence.
How does NNMT inhibition relate to NAD+?
NNMT uses nicotinamide as its substrate to produce 1-methylnicotinamide. Every nicotinamide molecule that gets methylated is one that can no longer be recycled into NAD+. When NNMT is overactive (as in obese adipose tissue), it drains the nicotinamide pool and limits NAD+ biosynthesis. Blocking NNMT with 5-Amino-1MQ preserves nicotinamide for NAD+ regeneration.
What does the research actually show?
The data is preclinical. In high-fat-diet mouse models, 5-Amino-1MQ has been reported to reduce body weight, white adipose mass, and adipocyte size, and a 2024 study found NNMT inhibition improved glucose tolerance and fatty-liver markers in diet-induced obese mice without reducing food intake - pointing to an adipose/energy-expenditure mechanism rather than appetite suppression. No human clinical efficacy has been established.
What half-life and oral bioavailability appear in the literature?
Rat pharmacokinetic studies describe roughly 38% oral bioavailability with a plasma half-life around 3.8 h IV and 6.9 h oral, and very high water solubility (>100 mg/mL). That oral profile is unusual for a metabolic compound and is one reason it is studied with once-daily oral protocols. No human PK data has been published.
How is 5-Amino-1MQ different from MOTS-c?
Both are studied for metabolism, but they are structurally and mechanistically different. 5-Amino-1MQ is a small-molecule NNMT inhibitor that preserves NAD+/SAM pools, while MOTS-c is a 16-amino-acid mitochondrial-derived peptide that activates AMPK as an "exercise mimetic". One is an enzyme inhibitor taken orally; the other is an injectable signalling peptide.
How should 5-Amino-1MQ be stored?
Unlike most peptides on this site, 5-Amino-1MQ is a stable small molecule that does not require freezing. Store it in a cool, dry place at room temperature; it is shelf-stable in that state.
Is this page medical advice? Can I use 5-Amino-1MQ for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find 5-Amino-1MQ specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside 5-Amino-1MQ.
Scientific sources & further reading
Primary literature and registries for 5-Amino-1MQ, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: 5-Amino-1MQ, 5-Amino-1-Methylquinolinium, 5-AMQ, NNMT Inhibitor, 5-Amino-1-Methylquinolinium Iodide, NNMT-I
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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