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Tesamorelin: HGH / Somatropin research guide
In short: Tesamorelin, FDA-approved synthetic GHRH(1-44) analogue with N-terminal hexenoic acid modification for DPP-IV resistance and pulsatile GH release. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.
Not medical advice. Tesamorelin is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
Tesamorelin at a glance
What to know first
Details and limits sit in the sections below. Research use only.
What Tesamorelin is
Tesamorelin is an FDA-approved synthetic GHRH(1-44) analog engineered for DPP-IV resistance, studied for visceral fat reduction, IGF-1 elevation, and metabolic research.
One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.
Tesamorelin, FDA-approved synthetic GHRH(1-44) analogue with N-terminal hexenoic acid modification for DPP-IV resistance and pulsatile GH release.
Research contexts
Peer-reviewed papers discuss Tesamorelin in specific lab settings. The points below reflect research questions, not health claims.
Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.
Typical study contexts
Why HGH / Somatropin research matters
Growth-hormone axis peptides are studied for GH/IGF signalling in animals and cells. Focus stays on endocrine biology, not prescribing.
Mechanisms (technical review)
Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.
Lab handling & preparation
Common Questions People Are Asking
What is tesamorelin?
Tesamorelin is a synthetic 44-amino-acid analogue of growth-hormone-releasing hormone (GHRH) stabilised with an N-terminal hexenoic acid. It signals the pituitary to release growth hormone and is the molecule approved (as Egrifta) to reduce excess visceral fat in HIV-associated lipodystrophy. New-U's tesamorelin is research-grade material supplied for laboratory use only — not the approved drug and not for human use.
What does tesamorelin do?
In the research and clinical literature tesamorelin activates the pituitary GHRH receptor to raise growth hormone and IGF-1, with a notable effect on visceral (deep abdominal) adipose tissue. These are findings for the molecule; New-U supplies research-grade tesamorelin for laboratory research only and implies no human therapeutic effect.
What is tesamorelin used for?
Clinically the approved drug is used to reduce visceral fat in HIV-associated lipodystrophy. In the research literature it is a tool compound for GH-axis and adipose-tissue studies. New-U supplies research-grade tesamorelin strictly for in-vitro and animal-model research, not for human use.
Is tesamorelin FDA approved?
The pharmaceutical tesamorelin (Egrifta) is FDA-approved for HIV-associated lipodystrophy. That approval applies to the finished prescription drug — NOT to research-grade material. New-U's tesamorelin is an unapproved research powder supplied for laboratory research only and is not a substitute for the prescription product.
Is tesamorelin safe?
As the approved drug Egrifta, tesamorelin has a human safety dataset under medical supervision. That record does not extend to research-grade material, which is not a sterile approved medicine and carries no human safety assurances. New-U supplies it for laboratory research only and makes no human-use claims.
How is tesamorelin different from sermorelin or CJC-1295?
All three are GHRH analogs, but tesamorelin is a full 44-amino-acid version with an N-terminal hexenoic acid for DPP-IV resistance. Sermorelin is the shorter 29-residue truncation with a shorter half-life, and CJC-1295 uses either tetrasubstitution (no-DAC) or covalent albumin binding (DAC) for different duration profiles. Tesamorelin has the strongest clinical dataset.
Tesamorelin vs ipamorelin — what is the difference?
They act on opposite ends of the same axis: tesamorelin is a GHRH-receptor analogue acting upstream on the pituitary, while ipamorelin is a selective ghrelin-receptor (GHSR) agonist. Tesamorelin has the heavier clinical dataset and a specific visceral-fat signal, whereas ipamorelin is prized for clean GH release with minimal cortisol or prolactin effect. Because they engage different receptors, the two are studied together as a complementary GHRH + secretagogue pairing rather than as substitutes.
Why does tesamorelin reduce visceral fat specifically?
GH itself preferentially mobilises visceral adipose tissue because visceral fat is more sensitive to catecholamine and GH-driven lipolysis than subcutaneous fat. Tesamorelin generates a physiologic GH pulse that targets exactly this compartment, which is why VAT drops while SAT is largely preserved.
Does tesamorelin raise blood sugar?
Like any GH-driven protocol, tesamorelin can transiently raise fasting glucose and worsen insulin sensitivity because GH opposes insulin action. Clinical trials reported modest glycemic changes that are typically manageable but warrant monitoring in research protocols.
How should tesamorelin be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C, protect from light, and use within the peptide's typical stability window. Avoid shaking, which can denature the peptide.
What happens if you stop taking peptides?
Tesamorelin is a GHRH analogue studied for its effect on visceral fat via the body's own GH release. The published clinical literature on the reference drug reports that the visceral-fat reduction is not maintained after the peptide is discontinued — visceral adipose tissue tends to return toward baseline — because the effect depends on ongoing GH-axis stimulation rather than a permanent change. Those findings describe the approved medicine in human studies; tesamorelin here is an unapproved research-grade peptide for laboratory research only and is not for human use.
Is this page medical advice? Can I use Tesamorelin for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find Tesamorelin specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside Tesamorelin.
Scientific sources & further reading
Primary literature and registries for Tesamorelin, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: TH-9507, Growth Hormone Releasing Factor 1-44 Analogue, trans-3-Hexenoic Acid GHRH, Tesamorelin Acetate
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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